II Boom allergies attention to the protein

The greater the presence of TSLP, more intense will be the noise. But behind the increase in recent years, there's too much of certain aseptic environments ELENA Dusi 

It starts with the skin reddened, then get a food allergy, followed by hay fever and closes with a principle of asthma. While the kids sneeze, parents and doctors are scratching their heads. Where does "the march of allergic reaction" that brings up a disturbance after another, especially in the first years of life, especially in developed countries, in fact, was until recently a mystery. 

Now research published in Nature reveals in part the mechanism of which overlap multiple allergies in children and in fact that doctors have christened "the march of allergies." To light the match that will turn into a fire is one of the many soldiers of our immune system. TSLP is called, is a protein that may be present in the body in amounts larger or smaller depending on the type of genes with which each of us is born. The greater its presence, the more intense and varied are the problems. Researchers at the University of Pennsylvania have realized that TSLP acts as a principal, but the perpetrators of the fire are relatively rare immune system cells, basophils, that when they are "armed" by TSLP proteins begin to trigger reactions adverse reactions in various tissues. 

This is why an itch on the skin appeared in danger of becoming a children's hay fever or food allergy. The affected organs are completely different, but all suffer the effects of basophils, cells that flow in the blood and tissues are specialized in inflammation in which they pass. The study conducted on mice was confirmed by examining the white blood cells in a group of children with food allergies. Even in their case, the production of basophils was much steeper than children without disorders. "Our discovery may help us find new drugs against the boom of allergies," says David Artis team leaders, microbiologist at the University of Pennsylvania.
American researchers have revealed a complex chain of rings that sets in motion allergies. Surely by now will be easier to build a "cutter" to break. But the ultimate cause of these disorders remains uncertain, and above all there are no definitive answers as to why allergies have been exponential increases in recent decades. 

The most likely hypothesis is that "toilet". If a newborn baby is found in an aseptic environment, your immune system is no enemy against which lash and does not receive the proper imprinting. In the absence of microbes and pathogens, cells soldiers would end up blaming opponents so for non-existent, as the harmless pollen. The phenomenon was noticed for the first time in Austria, where he measured a rate of allergies among children living on the farm up to 50 percent lower than children in cities. According to this theory, the excess would be cleaned at the base of the huge increase in allergies, which in Western countries has increased from 10 percent in 1980 to 30 percent today, with peaks of 40 percent for the spring pollen rhinitis.

Source repubblica.it